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Risk of nodal disease in patients with MRI-detected extramural vascular invasion in rectal cancer: a systematic review and meta-analysis.
CONCLUSION: The probability of positive lymph nodes in cases of positive mrEMVI is distinctly greater compared with negative cases in rectal cancer. Positive mrEMVI indicates risk of nodal disease prevalence increased by threefold in rectal cancer. PMID: 33243105 [PubMed - as supplied by publisher]
Source: Tumori - November 29, 2020 Category: Cancer & Oncology Tags: Tumori Source Type: research

Vascular Resection for Pancreatic Cancer: 2019 French Recommendations Based on a Literature Review From 2008 to 6-2019
Conclusion: For PDAC with vascular involvement, neoadjuvant treatment followed by pancreatectomy with venous resection or even arterial resection can be proposed as a curative option in selected patients with selected vascular involvement.
Source: Frontiers in Oncology - February 3, 2020 Category: Cancer & Oncology Source Type: research

Management of rectal cancer: Times they are changing
Publication date: Available online 5 August 2014 Source:GE Jornal Português de Gastrenterologia Author(s): Marilia Cravo , Tania Rodrigues , Susana Ouro , Ana Ferreira , Luis Féria , Rui Maio Approximately one third of all colorectal malignancies are located in the rectum. It has long been recognized that rectal cancers behave differently from colonic tumors, namely in terms of local recurrence. For this reason, specific protocols have been developed to manage this disease both in staging procedures as well as in neoadjuvant and adjuvant chemoradiation treatments. Magnetic resonance imaging is now obligatory for rectal...
Source: GE Jornal Portugues de Gastrenterologia - November 1, 2014 Category: Gastroenterology Source Type: research

The prognostic value of MRI-detected extramural vascular invasion (mrEMVI) for rectal cancer patients treated with neoadjuvant therapy: a meta-analysis
ConclusionmrEMVI and ymrEMVI positivity are poor prognostic factors for rectal cancer patients treated with neoadjuvant therapy. The precise evaluation of EMVI may contribute to designing individualised treatments and improving patient outcomes.Key Points• Extramural vascular invasion (EMVI) is a prognostic factor for rectal cancer.• MRI can be used to evaluate EMVI status before (mrEMVI) and after neoadjuvant therapy (ymrEMVI).• The evaluation of mrEMVI and ymrEMVI in neoadjuvant therapy would provide an early assessment of patient prognosis.
Source: European Radiology - May 15, 2021 Category: Radiology Source Type: research

Breast cancer chemotherapy induces vascular dysfunction and hypertension through NOX4 dependent mechanism
J Clin Invest. 2022 May 26:e149117. doi: 10.1172/JCI149117. Online ahead of print.ABSTRACTCardiovascular disease is the major cause of morbidity and mortality in breast cancer survivors. Chemotherapy contributes to this risk. We aimed to define the mechanisms of long-term vascular dysfunction caused by neoadjuvant chemotherapy (NACT) and identify novel therapeutic targets.We studied arteries from postmenopausal women who had undergone breast cancer treatment using docetaxel, doxorubicin and cyclophosphamide (NACT), and women with no history of such treatment matched for key clinical parameters. Mechanisms were explored in ...
Source: Clinical Breast Cancer - May 26, 2022 Category: Cancer & Oncology Authors: Piotr Szczepaniak Mateusz Siedlinski Diana Hodorowicz-Zaniewska Ryszard Nosalski Tomasz P Mikolajczyk Aneta M Dobosz Anna Dikalova Sergey Dikalov Joanna Streb Katarzyna Gara Pawel Basta Jaroslaw Krolczyk Joanna Sulicka-Grodzicka Ewelina Jozefczuk Anna Dzi Source Type: research

Surgical Treatment of Pancreatic Cancer: Currently Debated Topics on Vascular Resection
Cancer Control. 2023 Jan-Dec;30:10732748231153094. doi: 10.1177/10732748231153094.ABSTRACTVascular resections involving the superior mesenteric and portal veins (SMV-PV), celiac axis (CA), superior mesenteric artery (SMA) and hepatic artery (HA) have multiplied in recent years, raising the resection rate for pancreatic cancer (PDAC) and the related morbidity and mortality rates. While resection is generally accepted for resectable SMV-PV, the usefulness of associated arterial resection in borderline resectable (BRPC) and locally-advanced PDAC (LAPC) is much debated. Careful selection of splenic vein reconstruction is very ...
Source: Cancer Control - January 24, 2023 Category: Cancer & Oncology Authors: Sergio Pedrazzoli Source Type: research

Pancreatic Cancer with Vascular Involvement: Adherence to Current Standard-of-Care Associated with Improved Survival
CONCLUSIONS: Most resected pancreatic cancer patients in this study with vascular involvement receive either postoperative or no adjuvant therapy. N-MAC increases downstaging, R0 resection rates, and survival.PMID:36854081 | DOI:10.1177/00031348231156756
Source: The American Surgeon - February 28, 2023 Category: Surgery Authors: Abdimajid Mohamed Laura Nicolais Timothy L Fitzgerald Source Type: research

Prognostic Value of Vascular Invasion in Pediatric Osteosarcomas.
Abstract Metastatic status, histologic response, and quality of surgical resection are prognostic factors for osteosarcomas. Pathology reports sometimes describe peritumoral vascular invasion on surgical specimens after neoadjuvant chemotherapy but their prognostic significance as an independent parameter has never been reported. The aim of this study was to evaluate how the presence of this peritumoral vascular invasion could influence survival. We retrospectively analyzed histology, demographics, and outcomes of pediatric patients treated for osteosarcoma in our institutions between January 2007 and December 201...
Source: Pathology Oncology Research - May 25, 2016 Category: Pathology Authors: Benezech S, Chabaud S, Chambon F, Dijoud F, Chotel F, Marec-Berard P Tags: Pathol Oncol Res Source Type: research

Extramural vascular invasion as an independent prognostic marker in locally advanced rectal cancer: propensity score match pair analysis
CONCLUSION: Extramural vascular invasion detected through MRI is an independent risk factor for distant metastasis in the locally advanced carcinoma rectum. Aggressive treatment regimens like total neoadjuvant treatment should be considered in these cases pending randomized control studies.PMID:36085377 | DOI:10.1007/s00261-022-03608-z
Source: Cancer Control - September 10, 2022 Category: Cancer & Oncology Authors: Sonz Paul Supreeta Arya Smruti Mokul Akshay Baheti Suman Kumar Anant Ramaswamy Vikas Ostwal Supriya Chopra Avanish Saklani Ashwin deSouza Mufaddal Kazi Reena Engineer Source Type: research

MRI vs. CT for pancreatic adenocarcinoma vascular invasion: comparative diagnostic test accuracy systematic review and meta-analysis
ConclusionsBased on limited data, no difference was observed between MRI and pancreatic protocol CT for PDAC vascular invasion assessment. MRI may be an adequate substitute for pancreatic protocol CT in some patients, particularly those who have already had a single-phase CT. Larger and more recent cohort studies at low risk of bias, including patients who have received neoadjuvant therapy, are needed.Clinical relevance statementAbdominal MRI performed similarly to pancreatic protocol CT at assessing pancreatic ductal adenocarcinoma vascular invasion, suggesting local staging is adequate in some patients using MRI. More da...
Source: European Radiology - April 21, 2023 Category: Radiology Source Type: research

Evaluation of the treatment response to neoadjuvant chemotherapy in locally advanced breast cancer using combined magnetic resonance vascular maps and apparent diffusion coefficient
ConclusionThe early changes of MR vascular maps and ADC are associated with the final treatment response of LABC. J. Magn. Reson. Imaging 2015.
Source: Journal of Magnetic Resonance Imaging - April 15, 2015 Category: Radiology Authors: Li‐An Wu, Ruey‐Feng Chang, Chiun‐Sheng Huang, Yen‐Shen Lu, Hong‐Hao Chen, Jo‐Yu Chen, Yeun‐Chung Chang Tags: Original Research Source Type: research

Preoperative CT staging of borderline pancreatic cancer patients after neoadjuvant treatment: accuracy in the prediction of vascular invasion and resectability
ConclusionTumor –vessel criteria demonstrated good diagnostic performance and reproducibility in the prediction of vascular invasion after NAT in BRPC. These criteria could be helpful in the prediction of R0 resection in cases with only venous involvement.
Source: Abdominal Imaging - May 31, 2020 Category: Radiology Source Type: research